Endocrine Abstracts

We recently identified a group of neurons in the arcuate nucleus of the mammalian hypothalamus that co-localize three neuropeptides, kisspeptin, neurokinin B and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that this subpopulation, abbreviated as the ‘KNDy’ subpopulation, plays a key role in mediating hormonal feedback control of GnRH secretion. KNDy cells are a major target for ster...